The adequacy of subendocardial oxygen delivery: the interaction of determinants of flow, arterial oxygen content and myocardial oxygen need.

نویسندگان

  • J Brazier
  • N Cooper
  • G Buckberg
چکیده

oxygen delivery per unit of TTI was significantly lowered and Endo ECGs showed ischemia (ST elevation) when Endo/Epi flow ratios (microsphere method) fell below 1.0 (P < 0.001). Ischemia occurred without anemia (Hgb > 10 g %) in severe aortic stenosis; with mild anemia (Hgb 5-10 g %) and mild aortic stenosis; and with severe anemia (Hgb < 5 g %) without aortic stenosis. Ischemic Endo ECGs occurred with mild supravalvar aortic stenosis and mild anemia despite a 63% (92 to 150 cc/100 g/min) average increase in subendocardial flow while Epi ECGs remained normal. Altered flow distributions and abnormal ECGs were always predictable from the ratio: DPTI X 02 content (Supply)/TTI (Demand). These determinants of Supply and Demand are readily obtained from measurements of hemoglobin, saturation, and blood

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عنوان ژورنال:
  • Circulation

دوره 49 5  شماره 

صفحات  -

تاریخ انتشار 1974